In the other pairings, English champions Manchester United will take on Greek club Olympiakos, while AC Milan take on Atletico Madrid.
Arsenal's Eddie Nketiah's two goals enough to beat Oxford United
Striker Robin van Persie has recovered from a groin strain and returns to Arsenal's squad for the Champions League semi-final second leg against holders Manchester United on Tuesday, manager Arsene Wenger said.
Arsenal produced a scintillating display of attacking football to crush Crystal Palace 5-1.
Cesc Fabregas scored twice to send Arsenal second in the Premier League, four points behind Chelsea but with a game in hand, after brushing aside Aston Villa 3-0 at the Emirates Stadium on Sunday.
Manager Roy Hodgson has hinted that Liverpool are unlikely to mount a Premier League title challenge this season.
Chelsea lost for the sixth time in six games in all competitions since interim coach Frank Lampard replaced Graham Potter last month, a dismal run for a club who were crowned European champions as recently as two years ago.
Arsenal went top of the Premier League when they beat West Ham United 2-0 with goals from Denilson and Cesc Fabregas on Saturday despite playing for more than half the match at the Emirates with 10 men.
Liverpool climbed to the top of the Premier League table with a 2-1 victory over struggling Wolverhampton Wanderers on Saturday.
Reading enjoyed a memorable first taste of the top flight when they beat Middlesbrough 3-2.
The teams clash at the Etihad stadium on Sunday (1700 IST) with United three points clear of champions City.
Stunning hat-tricks from Dimitar Berbatov and Robin van Persie moved Manchester United and Arsenal ahead in the Premier League title race as strikers took the spotlight on Saturday.
Arsenal are buzzing after their resounding victory over north London rivals Tottenham Hotspur but they go into Wednesday's Champions League home clash with Montpellier aware that any slip could be costly to their last 16 hopes.
A round-up of the weekend's action in the major European leagues.
Phil Foden kept Manchester City's Premier League title challenge on track with a superb second-half double as his side hit back to clinch a 3-1 home victory over Manchester United on Sunday.
Manchester United needed a stoppage-time equaliser to draw 1-1 with 10-man Blackburn Rovers in the English Premiership.
Images from the English Premier League matches played on Sunday.
Reigning champions Manchester City took the lead after 24 seconds but suffered a shock 2-1 defeat at Newcastle United.
Liverpool will resume their quest for a first top-flight title in 30 years at city rivals Everton on June 21, as the English Premier League released its revised fixture list for the first three weeks of the restarted season on Friday. Liverpool are 25 points clear at the top and are two victories away from winning the Premier League, but will have a shot at securing the title by beating Everton if City lose to Arsenal.
Arsenal's Olivier Giroud produced a piece of New Year's Day magic to keep Arsenal in sight of Premier League leaders Chelsea while Harry Kane's double bolstered Tottenham Hotspur's ambitions as London's triple assault on the title continues.
Manchester United stretched their unbeaten run to 11 games in all competitions after Daley Blind, in-form striker Zlatan Ibrahimovic and substitute Henrik Mkhitaryan gave them a 3-1 home win over Sunderland on Monday. Left back Blind fired United ahead with a crisp 39th-minute shot after Ibrahimovic teed him up perfectly. The towering Swede doubled the lead with a clinical 82nd-minute finish for his 17th goal of the season. Fit-again Mkhitaryan put the icing on the cake with a spectacular backheel effort after a sharp Ibrahimovic cross from the right, although television replays suggested the Armenian was marginally offside. Striker Fabio Borini gave Sunderland fans something to cheer with a dipping late volley.
Manchester United were celebrating their eighth premier league title in 11 seasons on Sunday after Arsenal lost 3-2 at home to Leeds.
Manchester United needed a stunning second-half equaliser from Wayne Rooney and a rare goal from Wes Brown to beat Newcastle United 2-1.
Manchester United beat Liverpool 2-1 with goals from Wayne Rooney and Park Ji-sung to send the champions back to the top of the Premier League on Sunday.
Images from the English Premier League matches played on Sunday.
Chelsea's terrible start to the season plumbed new depths on Saturday when the Premier League champions lost 2-1 at West Ham United.
Arsenal beat north London rivals Tottenham Hotspur 3-1 to surge top of the English Premier League.
The Arsenal manager believes Manchester United will bounce back next season after the blow of losing the FA Cup final to his Arsenal team.
Alexis Sanchez is facing a crucial period to justify his big-money wages at Old Trafford.
IMAGES from the EPL matches played on Wednesday.
Aaron Ramsey indulged his new goalscoring habit on his return to his boyhood club as Arsenal opened up a seven-point lead at the top of the Premier League with a 3-0 victory at Cardiff City on Saturday.
Aston Villa blew a chance to go eight points clear of Arsenal in the race for England's fourth Champions League berth Sunday after conceding two late goals against relegation-threatened Stoke City. The 2-2 draw, with Stoke cancelling out their hosts' 2-0 lead in the final three minutes, left fourth-placed Villa six points ahead of Arsenal and three adrift of second-placed Chelsea and Liverpool in the Premier League.