Arsenal and Liverpool drew 1-1 for the third time this season on Saturday as the London side's Premier League title hopes suffered another blow. Arsenal could now end the weekend eight points behind league leaders Manchester United with five games left.
Bethany England's early rocket proved enough for Chelsea as they beat newcomers Tottenham Hotspur 1-0.
In the other pairings, English champions Manchester United will take on Greek club Olympiakos, while AC Milan take on Atletico Madrid.
Striker Robin van Persie has recovered from a groin strain and returns to Arsenal's squad for the Champions League semi-final second leg against holders Manchester United on Tuesday, manager Arsene Wenger said.
Arsenal produced a scintillating display of attacking football to crush Crystal Palace 5-1.
Images from the Premier League matches played on Tuesday.
Cesc Fabregas scored twice to send Arsenal second in the Premier League, four points behind Chelsea but with a game in hand, after brushing aside Aston Villa 3-0 at the Emirates Stadium on Sunday.
Manager Roy Hodgson has hinted that Liverpool are unlikely to mount a Premier League title challenge this season.
Arsenal went top of the Premier League when they beat West Ham United 2-0 with goals from Denilson and Cesc Fabregas on Saturday despite playing for more than half the match at the Emirates with 10 men.
Reading enjoyed a memorable first taste of the top flight when they beat Middlesbrough 3-2.
West Ham beat Premier League strugglers Leicester City 2-0 at the London Stadium on Thursday thanks to an early strike from Tomas Soucek on his 30th birthday and an own goal just before halftime.
The teams clash at the Etihad stadium on Sunday (1700 IST) with United three points clear of champions City.
Stunning hat-tricks from Dimitar Berbatov and Robin van Persie moved Manchester United and Arsenal ahead in the Premier League title race as strikers took the spotlight on Saturday.
Arsenal are buzzing after their resounding victory over north London rivals Tottenham Hotspur but they go into Wednesday's Champions League home clash with Montpellier aware that any slip could be costly to their last 16 hopes.
Liverpool moved to 76 points from 32 games with title rivals Manchester City on 74 points from one game fewer, with Pep Guardiola's side hosting Brighton and Hove Albion at the Etihad on Wednesday.
Chelsea climbed back into contention for next season's Champions League with a 1-0 home win over Everton in the Premier League on Saturday thanks to a fine first-half strike by Nicolas Jackson.
A round-up of the weekend's action in the major European leagues.
Manchester United needed a stoppage-time equaliser to draw 1-1 with 10-man Blackburn Rovers in the English Premiership.
Manchester United were celebrating their eighth premier league title in 11 seasons on Sunday after Arsenal lost 3-2 at home to Leeds.
Manchester United stretched their unbeaten run to 11 games in all competitions after Daley Blind, in-form striker Zlatan Ibrahimovic and substitute Henrik Mkhitaryan gave them a 3-1 home win over Sunderland on Monday. Left back Blind fired United ahead with a crisp 39th-minute shot after Ibrahimovic teed him up perfectly. The towering Swede doubled the lead with a clinical 82nd-minute finish for his 17th goal of the season. Fit-again Mkhitaryan put the icing on the cake with a spectacular backheel effort after a sharp Ibrahimovic cross from the right, although television replays suggested the Armenian was marginally offside. Striker Fabio Borini gave Sunderland fans something to cheer with a dipping late volley.
Wolves took the lead a minute later when Rayan Ait-Nouri's cross found Sarabia poorly marked in the middle of the box. The Spain international headed past Grbic to score his third goal in the campaign.
Arsenal's Olivier Giroud produced a piece of New Year's Day magic to keep Arsenal in sight of Premier League leaders Chelsea while Harry Kane's double bolstered Tottenham Hotspur's ambitions as London's triple assault on the title continues.
Manchester United needed a stunning second-half equaliser from Wayne Rooney and a rare goal from Wes Brown to beat Newcastle United 2-1.
Reigning champions Manchester City took the lead after 24 seconds but suffered a shock 2-1 defeat at Newcastle United.
Manchester United beat Liverpool 2-1 with goals from Wayne Rooney and Park Ji-sung to send the champions back to the top of the Premier League on Sunday.
Chelsea's terrible start to the season plumbed new depths on Saturday when the Premier League champions lost 2-1 at West Ham United.
Arsenal's Eddie Nketiah's two goals enough to beat Oxford United
Arsenal beat north London rivals Tottenham Hotspur 3-1 to surge top of the English Premier League.
The Arsenal manager believes Manchester United will bounce back next season after the blow of losing the FA Cup final to his Arsenal team.
Third-placed Aston Villa are the surprise package of the season and Unai Emery's side face relegation-threatened Burnley while fifth-placed Spurs host a resurgent Bournemouth who have 19 points from their last seven games.
Aaron Ramsey indulged his new goalscoring habit on his return to his boyhood club as Arsenal opened up a seven-point lead at the top of the Premier League with a 3-0 victory at Cardiff City on Saturday.
Liverpool will resume their quest for a first top-flight title in 30 years at city rivals Everton on June 21, as the English Premier League released its revised fixture list for the first three weeks of the restarted season on Friday. Liverpool are 25 points clear at the top and are two victories away from winning the Premier League, but will have a shot at securing the title by beating Everton if City lose to Arsenal.